Ronan Curtis could return to the side after playing the final 20 minutes against Cheltenham, with Tottenham loanee Dane Scarlett likely to make way. Mamadou Jobe could miss out once again for Cambridge.
Clearly in confident mood after knocking Cardiff out of the Carabao Cup four days earlier, Portsmouth won comfortably at Cheltenham on Saturday to put their first league win of the season on the board. Cambridge are one point ahead of the hosts after securing a third home win in league and cup already this term, beating Exeter 2-1. The U's avoided defeat in each of their three meetings with Portsmouth last season, winning two, but their 2-1 win at Fratton Park last September was their first ever victory on Pompey soil. 1:0
Portsmouth are undefeated in their last 11 home matches (League One). Portsmouth have seen over 2.5 goals in their last 4 home matches against Cambridge U in all competitions.