Fred and Edinson Cavani returned late from international duty and missed the 4-2 loss at Leicester on Saturday, but will hope to feature against Atalanta. Raphael Varane, Amad Diallo and Anthony Martial all miss out, though Harry Maguire made a quicker return to action than expected and should start in defence. Aaron Wan-Bissaka's ban was reduced to one game, so the right-back is available for Ole Gunnar Solskjaer. With Hans Hateboer and Robin Gosens ruled out here through injury, Davide Zappacosta and Joakim Maehle are set to to start at right and left wing-back, respectively. Matteo Pessina and Berat Djimsiti join the pair on the sidelines. Josip Ilicic will be hoping his brace against Empoli will be enough to start at Old Trafford on Wednesday night.