Cristian Romero and Son Heung-Min both remain absent for Tottenham, while Steven Bergwijn, who has been linked with a move to Ajax, is still classed as a doubt having failed to make the squad for Sunday's FA Cup win over Morecambe. Eric Dier is also ruled out, meaning Japhet Tanganga, Davinson Sanchez and Ben Davies are likely to start in a three-man defence once again. Giovani Lo Celso was the star man against Morecambe and he could be rewarded with a place in the side on Wednesday night. Edouard Mendy is with the Senegal national team for AFCON and is absent, while Reece James, Trevoh Chalobah and Ben Chilwell are sidelined due to injury. Thiago Silva and N'Golo Kante have both recently endured stints on the sidelines owing to positive COVID-19 tests, but the pair may return for Wednesday's London derby. Thomas Tuchel started his side in a four-man backline in the first leg, but may revert to a three-man defence here.