Moussa Niakhaté is out for several weeks with a thigh injury, while Aarón Martín has a groin injury. Marcus Ingvartsen scored on debut after joining on loan from Union Berlin this summer. Maximilian Eggestein will bolster midfield as record signing Baptiste Santamaria has moved back to France in a switch to Rennes. Nicolas Höfler is struggling with injury so Eggestein could be in line for a start. Nils Petersen has returned from a knee operation, Jonathan Schmid tested positive for COVID-19, so Lukas Kübler could slot in on the left.
Freiburg will be a tough nut to crack for fourth-placed Mainz, who were marvellous towards the end of last season and have overcome COVID-19 problems well this time around to start with three wins out of four. Freiburg are unbeaten in four themselves and sit one spot below Mainz. A draw could be a good shout here. 1:1
SC Freiburg 
Mainz VS SC Freiburg 
SC Freiburg 