Sam Baldock and Yanic Wildschut both remain out for the hosts. Mark Bonner could stick with the same XI that started the opening day victory over MK Dons.
Oxford were moments away from claiming a point at a red-hot Pride Park last weekend, but Conor Hourihane's late strike ensured their season got off to the worst possible start. It's not unfamiliar territory for the U's, though, with Karl Robinson's side failing to win their first fixture in any of the last five years. With their EFL Cup first round tie against Millwall played a week earlier, Cambridge are already gathering some early-season momentum, with two 1-0 victories from their first two competitive fixtures. But if the away side want to keep up their 100% start, they'll have to win at the Kassam Stadium for the first time since January 1978. 1:0